An overview of muscle glucose uptake during exercise. Sites of regulation.

摘要: The uptake of blood glucose by skeletal muscle is a complex process. In order to be metabolized, must travel the path from interstitium intracellular space and then phosphorylated 6-phosphate (G6P). Movement determined flow, capillary recruitment endothelial permeability glucose. influx number transporters in sarcolemma gradient across sarcolemma. capacity phosphorylate amount hexokinase II, II compartmentalization within cell, concentration inhibitor G6P. Any change occurs due an alteration one or more these steps. Based on low calculated levels higher affinity for phosphorylation relative transport, transport generally considered rate-determining basal uptake. Exercise increases both movement Whether ability increased working remains clearly shown. It possible that accelerated delivery rates during exercise bias regulation so exerts control Conditions alter exercise, such as NEFA concentrations, decreased oxygen availability adrenergic stimulation, work altering three steps involved This review describes at each sites under conditions, well describing post-exercise state.