Liposome encapsulated berberine treatment attenuates cardiac dysfunction after myocardial infarction
作者： Iris E. Allijn , Bertrand M.S. Czarny , Xiaoyuan Wang , Suet Yen Chong , Marek Weiler
DOI: 10.1016/J.JCONREL.2016.12.042
关键词:
摘要: Inflammation is a known mediator of adverse ventricular remodeling after myocardial infarction (MI) that may lead to reduction ejection fraction and subsequent heart failure. Berberine isoquinoline quarternary alkaloid from plants has been associated with anti-inflammatory, anti-oxidative, cardioprotective properties. Its poor solubility in aqueous buffers its short half-life the circulation upon injection, however, have hampering extensive usage this natural product. We hypothesized encapsulation berberine into long circulating liposomes could improve therapeutic availability efficacy by protecting cardiac function against MI vivo. Berberine-loaded were prepared ethanol injection characterized. They contained 0.3 mg/mL drug 0.11 μm diameter. Subsequently they tested for IL-6 secretion inhibition RAW 264.7 macrophages protection C57BL/6J mice. In vitro, free significantly inhibited (IC50 = 10.4 μM), whereas encapsulated did not as it was released formulation time frame vitro study. vivo, berberine-loaded preserved at day 28 64% compared control berberine. conclusion, liposomal enhanced buffer preserves MI. This shows delivery improves identifies potential treatment
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