Plasma nociceptin/orphanin FQ levels are lower in patients with chronic ischemic cardiovascular diseases--A pilot study
作者： Miklós Krepuska , Péter Sótonyi , Csaba Csobay-Novák , Zoltán Szeberin , István Hartyánszky
DOI: 10.1016/J.REGPEP.2011.01.007
关键词:
摘要: Abstract Background Clinical studies are limited regarding the role of human nociceptin/orphanin FQ (N/OFQ) in ischemic cardiovascular diseases, which still number one cause death developed world. The aim our study was to measure plasma levels N/OFQ patients with chronic diseases a pilot study. Methods and results Our population consisted 22 presenting symptoms stable angina pectoris (SAP): 12 severe Canadian Cardiovascular Society (CCS) III–IV functional class, 10 milder SAP (CCS II–III). were also enrolled peripheral artery disease (9 intermittent claudication; 3 rest pain gangrene). Patients asked avoid any exertion or given analgetics for their pain. had no episodes chest limb 1 week before fasting blood samples taken measured by radioimmunoassay. 14 healthy subjects without cardiac risk factors served as control group. Conclusions significantly lower patient groups vs. (p
elsevier.com
sci-hub.se 参考文章(44)
K H Jhamandas, G Henderson, M Sutak, Antinociceptive and morphine modulatory actions of spinal orphanin FQ Canadian Journal of Physiology and Pharmacology. ,vol. 76, pp. 314- 324 ,(1998) , 10.1139/CJPP-76-3-314
John P. Williams, Jonathan P. Thompson, John McDonald, Timothy A. Barnes, Tom Cote, David J. Rowbotham, David G. Lambert, Human peripheral blood mononuclear cells express nociceptin/orphanin FQ, but not mu, delta, or kappa opioid receptors. Anesthesia & Analgesia. ,vol. 105, pp. 998- 1005 ,(2007) , 10.1213/01.ANE.0000278865.11991.9D
H Brooks, D C. Elton, D Smart, J D. Rowbotham, T A. McKnight, G D. Lambert, Identification of nociceptin in human cerebrospinal fluid: comparison of levels in pain and non-pain states Pain. ,vol. 78, pp. 71- 73 ,(1998) , 10.1016/S0304-3959(98)00130-4
Jean-Claude Meunier, Catherine Mollereau, Lawrence Toll, Charles Suaudeau, Christiane Moisand, Paul Alvinerie, Jean-Luc Butour, Jean-Claude Guillemot, Pascual Ferrara, Bernard Monsarrat, Honoré Mazarguil, Gilbert Vassart, Marc Parmentier, Jean Costentin, Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor. Nature. ,vol. 377, pp. 532- 535 ,(1995) , 10.1038/377532A0
Kabirullah Lutfy, Nigel T Maidment, Blockade of μ-opioid receptors reveals the hyperalgesic effect of orphanin FQ/nociceptin in the rat hot plate test British Journal of Pharmacology. ,vol. 131, pp. 1684- 1688 ,(2000) , 10.1038/SJ.BJP.0703746
Fiorella Fontana, Pasquale Bernardi, Carmine Pizzi, Santi Spampinato, Andrea Bedini, Emilio Merlo Pich, Plasma nociceptin/orphanin FQ levels rise after spontaneous episodes of angina, but not during induced myocardial ischemia Peptides. ,vol. 30, pp. 1705- 1709 ,(2009) , 10.1016/J.PEPTIDES.2009.06.018
M.A Czapla, H.C Champion, P.J Kadowitz, Nociceptin, An Endogenous Ligand for the ORL1 Receptor, has Vasodilator Activity in the Hindquarters Vascular Bed of the Rat Peptides. ,vol. 18, pp. 793- 795 ,(1997) , 10.1016/S0196-9781(97)00014-4
Hunter C. Champion, Philip J. Kadowitz, Nociceptin, an endogenous ligand for the ORL1 receptor, has novel hypotensive activity in the rat Life Sciences. ,vol. 60, pp. PL241- PL245 ,(1997) , 10.1016/S0024-3205(97)00087-8
William M. Armstead, Relationship between nociceptin/orphanin FQ and cerebral hemodynamics after hypoxia-ischemia in piglets American Journal of Physiology-heart and Circulatory Physiology. ,vol. 278, pp. 477- 483 ,(2000) , 10.1152/AJPHEART.2000.278.2.H477
Alec Vahanian, Helmut Baumgartner, Jeroen Bax, Eric Butchart, Robert Dion, Gerasimos Filippatos, Frank Flachskampf, Roger Hall, Bernard Iung, Jaroslaw Kasprzak, Patrick Nataf, Pilar Tornos, Lucia Torracca, Arnold Wenink, Silvia G Priori, Jean-Jacques Blanc, Andrzej Budaj, John Camm, Veronica Dean, Jaap Deckers, Kenneth Dickstein, John Lekakis, Keith McGregor, Marco Metra, João Morais, Ady Osterspey, Juan Tamargo, José Luis Zamorano, José Luis Zamorano, Annalisa Angelini, Manuel Antunes, Miguel Angel Garcia Fernandez, Christa Gohlke-Baerwolf, Gilbert Habib, John McMurray, Catherine Otto, Luc Pierard, Josè L Pomar, Bernard Prendergast, Raphael Rosenhek, Miguel Sousa Uva, Juan Tamargo, None, Guidelines on the management of valvular heart disease The Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology European Heart Journal. ,vol. 28, pp. 230- 268 ,(2006) , 10.1093/EURHEARTJ/EHL428