Composite Nanogels Based on Zeolite-Poly(ethylene glycol) Diacrylate for Controlled Drug Delivery.
作者： Catalina Paula Spatarelu , Anita-Laura (Radu) Chiriac , Bogdan Cursaru , Tanta-Verona Iordache , Ana-Mihaela Gavrila
DOI: 10.3390/NANO10020195
关键词:
摘要: This study presents the design of novel composites nanogels, based on poly(ethylene glycol) diacrylate and natural zeolite particles, that are able to act as materials with controlled drug delivery properties. Natural zeolite–nanogels composite, varying contents, were obtained by an inverse mini-emulsion technique loaded 5-fluorouracil, a widely used chemotherapeutic drug. Herein, possibility adjusting final properties means modifying preparation conditions was investigated. The prepared composite nanogels characterized dynamic light scattering (DLS), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA). In this tunable drug-loading capability, swelling behaviour, cytotoxicity, these could be highly attractive reservoirs.
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