Pulmonary 'mainline' granulomatosis: talcosis of intravenous methadone abuse.

摘要: Seventeen intravenous abusers of methadone underwent clinical, roentgenologic and physiologic assessment. Two complained dyspnea on exertion two had cor pulmonale. Of 15 patients whose fundi were examined, nine talc particles in their retinal vessels. The chest roentgenograms seven showed a diffuse pin-point micronodular pattern the also manifested volume loss, one with coalescence opacities simulating progressive massive fibrosis. Twelve some degree pulmonary dysfunction, 10 lowered steady state diffusing capacity 11 decreased flow rates (FEV1 MMF). There was no hyperinflation, but an increase residual volume. Corticosteroid therapy attempted ineffective. Necropsy patient who died revealed severe fibrosis granulomas lungs, liver, kidneys lymph nodes.