Soluble Factors of Amnion-Derived Cells in Treatment of Inflammatory and Fibrotic Pathologies

摘要: Inflammation is a complex defense mechanism characterized by leukocyte migration from the vasculature into damaged tissues and subsequent deposition of extracellular matrix resulting in tissue repair. The inflammatory process generally categorized an acute, rapid response, persistent but slowly evolving chronic condition, which may progress diseases. An excessive leads to overgrowth, hardening, and/or scarring tissues, defined as fibrosis. amnion has been used biomaterial medicine for over 100 years proven valuable treatment different pathological conditions including wound healing. In light recent reports, this article will review effects its cellular components within inflammatory-fibrotic scenario factors described so far that could be involved these immunomodulatory actions. As proof principles, we also discuss pre-clinical clinical applications where advantage taken anti-inflammatory anti-fibrotic properties. It conceivable local host environment placed have profound role influencing production function soluble shift towards steps triggering healing effect depends on time, dosage, location cytokine/growth factor amnion, together with influence microenvironment. Indeed, determining specific cascade events define given situation remains challenge.