Diclofenac-β-cyclodextrin binary systems: Physicochemical characterization and in vitro dissolution and diffusion studies
作者： Maria Letizia Manca , Marco Zaru , Guido Ennas , Donatella Valenti , Chiara Sinico
DOI: 10.1208/PT060358
关键词:
摘要: The aim of this work was to study the influence β-cyclodextrin (β-CD) on biopharmaceutic properties diclofenac (DCF). To purpose physicochemical characterization diclofenac-β-cyclodextrin binary systems performed both in solution and solid state. Solid phase using differential scanning calorimetry (DSC), powder x-ray diffractometry (XRD), Fourier transform infrared spectroscopy (FTIR). Phase solubility analyses, vitro permeation experiments through a synthetic membrane were solution. Moreover, DCF/β-CD interactions studied DMSO by1H nuclear magnetic resonance (NMR) spectroscopy. effects different preparation methods drug-to-β-CD molar ratios also evaluated. studies revealed 1∶1 M complexation DCF when freeze-drying method used for system. true inclusion freeze-dried system confirmed NMR spectroscopy, DSC, XRD, IR studies. dissolution that drug rate improved by presence CDs highest promptest release obtained with Diffusion silicone showed diffusion higher from saturated (control) than complexes, prepared DCF-β-CD ratios. However, complex able stabilize giving rise more regular profile.
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