Long-Range Vibrational Dynamics Are Directed by Watson-Crick Base Pairing in Duplex DNA.
作者： Gordon Hithell , Daniel J. Shaw , Paul M. Donaldson , Gregory M. Greetham , Michael Towrie
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摘要: Ultrafast two-dimensional infrared (2D-IR) spectroscopy of a 15-mer A–T DNA duplex in solution has revealed structure-dependent vibrational coupling and energy transfer processes linking bases with the sugar–phosphate backbone. Duplex melting induces significant changes positions off-diagonal peaks carbonyl ring-stretching modes adenine thymine vibrations phosphate group phosphodiester linkage. These indicate that Watson–Crick hydrogen bonding helix formation lead to unique arrangement base those unit. On basis observations from time-resolved 2D-IR data, we conclude rapid occur between backbone, mediated by additional located on deoxyribose moiety within same nucleotide. relaxation dynamics are insensitive melting, showing efficient intramolecular solvent via ph...
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