作者: MARIANN FRIIS-OTTESSEN , PAULA M. DE ANGELIS , AASA R. SCHJØLBERG , SOLVEIG N. ANDERSEN , OLE PETTER F. CLAUSEN
关键词:
摘要: Longstanding ulcerative colitis (UC) is a disease of chronic inflammation the colon. It associated with development colorectal cancer through multistep process including increasing degrees dysplasia and DNA-ploidy changes. However, not all UC patients will develop these characteristics even during lifelong disease, may therefore be divided into progressors who or cancer, non-progressors do exhibit such In present study, amount hTERT, catalytic subunit enzyme telomerase, was estimated by using peroxidase immunohistochemistry (IHC) in set progressor non-progressor colectomies. The protein levels colonic mucosa were compared, further comparisons between different categories dysplastic to status within made. Levels hTERT elevated when compared non-UC control samples, but no difference observed non-progressors. Ki67 significant degree expression lesions DNA-aneuploidy decreased as diploid lesions, stratified for classes morphology. Our results indicate an association aneuploidy UC-progressor colons, also possible protective mechanism Ki67, against malignant features UC-colon.