Significantly increased PELP1 protein expression in primary and metastatic triple-negative breast carcinoma: Comparison with GATA3 expression and PELP1's potential role in triple-negative breast carcinoma

摘要: PELP1 is a novel coregulator of nuclear hormone receptors and implicated in playing role driving breast cancer enhancing metastatic potential. The protein expression potential triple-negative carcinoma (TNBC) have not been well characterized. We investigated by immunohistochemistry primary tumors human tissues compared its with GATA-binding 3 (GATA3), diagnostic marker for TNBC. examined the GATA3 70 TNBC cases found that had significantly higher frequency to (96% versus 46%; P < .0001). mean extent score was also than GATA3's (3.87 ± 0.07 0.91 0.15; stronger staining intensity GATA3. Furthermore, immunoreactivity consistently maintained paired (100%). (100%) (40%) same (P These findings indicate much more sensitive TNBCs. may utility appropriate settings, such as history where negative GATA3, mammaglobin, GCDFP-15. diffuse strong most suggests be molecular target treatment hope this study will provide insights into