Triflimide: An Overlooked High‐Performance Catalyst of the Mukaiyama Aldol Reaction of Silyl Ketene Acetals with Ketones
作者： Han Yong Bae , Benjamin List
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摘要: The Mukaiyama aldol reaction is a widely applied carbon-carbon bond forming reaction. However, despite numerous well-established methods using aldehydes as acceptors, only few examples exist with ketones. Here we report highly practical catalytic approach to this transformation, namely, the triflimide catalyzed of silyl ketene acetals This method exhibits broad substrate scope, very rapid, tolerates functionalized substrates, and requires parts-per-million catalyst loadings preparative scale reactions up hundreds grams in excellent purity (>99 %).
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