In Vitro Analyses of the Toxicity, Immunological, and Gene Expression Effects of Cobalt-Chromium Alloy Wear Debris and Co Ions Derived from Metal-on-Metal Hip Implants

摘要: Joint replacement has proven to be an extremely successful and cost-effective means of relieving arthritic pain improving quality life for recipients. Wear debris-induced osteolysis is, however, a major limitation causes orthopaedic implant aseptic loosening, various cell types including macrophages, monocytes, osteoblasts, osteoclasts, are involved. During the last few years, there been increasing concern about metal-on-metal (MoM) hip replacements regarding adverse reactions metal debris associated with MoM articulation. Even though MoM-bearing technology was initially aimed extend durability reduce requirement revision, they have reported release at least three times more cobalt chromium ions than metal-on-polyethylene (MoP) replacements. As result, toxicity particles produced by bearing surfaces, both locally in periprosthetic space systemically, became concern. Several investigations carried out understand mechanisms responsible response wear debris. This review aims summarising vitro analyses toxicity, immunological, gene expression effects derived from implants.