The chimeric human/mouse model of angiogenesis.

摘要: Angiogenesis, the formation of new blood vessels from preexisting vessels, is an essential component many normal biological processes such as embryonic development, wound healing, and endometrial maturation in premenopausal women (1–3). This process similar to, but not identical with vasculogenesis, which associated development precursor cells termed angioblasts (4,5). Under physiological conditions complex cellular events controlling vascular are tightly regulated. However, when molecular biochemical mechanisms angiogenesis disrupted, uncontrolled neovascularization can contribute to a number pathologies. In fact, several clinically important human diseases characterized by abnormal including solid tumor growth, rheumatoid arthritis, diabetic retinopathy, psoriasis (1–3,6–8). Thus, pathological consequences impacts large segment population clearly demonstrates need for depth understanding mediators involved regulation angiogenesis. To this end, expanding body work has identified wide variety molecules potential targets antiangiogenic strategies network cytokines, cell adhesion receptors, proteolytic enzymes, extracellular matrix components (9–11). Interestingly, these discoveries were first use vitro vivo models.