Newborn Screening for Sickle Cell Disease in Liberia: A Pilot Study
作者： Venée N. Tubman , Roseda Marshall , Wilhemina Jallah , Dongjing Guo , Clement Ma
DOI: 10.1002/PBC.25875
关键词:
摘要: Background In malaria-endemic countries in West Africa, sickle cell disease (SCD) contributes to childhood mortality. Historically, Liberia had regions wherein hemoglobin S and beta-thalassemia trait were mutually exclusive. Data on hemoglobinopathies the Monrovia, capital, are outdated do not reflect urban migration. Updating epidemiology of SCD is necessary plan a public health clinical agenda. Neither newborn screening (NBS) nor tools available country. This pilot study aimed determine feasibility NBS using South–South partnership define incidence (SCT) Monrovia. Procedure This descriptive epidemiologic collected dried blood spots from 2,785 consecutive newborns delivered at hospital Monrovia. Samples analyzed by isoelectric focusing regional reference laboratory. Infants with referred for preventive care. Results SCT occurred 10.31% infants screened. 33 screened [1.19% (95% confidence interval [CI]: 0.79–1.59%)] (FS: 28/33, FSB: 2/33, FSA: FSX: 1/33). There no FSC phenotype observed. Nonsickling phenotypes “FC” “F” each present three Seventy-six percent brought care, demonstrating our approach. Conclusions The other remains high Liberia. Additional studies needed clarify genotypes identify contribution silent alleles. By developing partnerships, similar can acquire current data inform as an important initiative toward improving child health.
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