Oral premedication for paediatric ambulatory anaesthesia: a comparison of midazolam and ketamine.

作者: P. J. Alderson , J. Lerman

DOI: 10.1007/BF03009834

关键词:

摘要: To compare the clinical characteristics of two oral premedicants, midazolam and ketamine, 40 healthy children, one to six years age, who were scheduled for ambulatory dental surgery, assigned receive either 0.5 mg.kg-1 or ketamine 5.0 in a double-blind, randomized study. Sedation anxiolysis scores before induction, cooperation at induction anaesthesia recovery times complications assessed. We found that both drugs effectively sedated children within 20 min administration. Although sedated, 10% group 20% those became tearful on separation from their parents 35% when facemask was applied. No important side effects attributable premedication. The time until fit discharge hospital after approximately less than ketamine. In conclusion, offer similar used as premedications undergoing although may be more rapid

参考文章(10)
C. O. McMillan, I. A. Spahr-Schopfer, N. Sikich, E. Hartley, J. Lerman, Premedication of children with oral midazolam Canadian Journal of Anaesthesia-journal Canadien D Anesthesie. ,vol. 39, pp. 545- 550 ,(1992) , 10.1007/BF03008315
I.S. GRANT, W.S. NIMMO, J.A. CLEMENTS, PHARMACOKINETICS AND ANALGESIC EFFECTS OF I.M. AND ORAL KETAMINE BJA: British Journal of Anaesthesia. ,vol. 53, pp. 805- 810 ,(1981) , 10.1093/BJA/53.8.805
J. Olney, J Labruyere, G Wang, D. Wozniak, M. Price, M. Sesma, NMDA antagonist neurotoxicity: mechanism and prevention. Science. ,vol. 254, pp. 1515- 1518 ,(1991) , 10.1126/SCIENCE.1835799
A.K. Sethi, R. Chawla, A. Bhattacharya, Intra-operative airway maintenance for short ophthalmological procedures in children. Anaesthesia. ,vol. 46, pp. 1084- 1084 ,(1991) , 10.1111/J.1365-2044.1991.TB09935.X
Howard B. Gutstein, Kristen L. Johnson, Maurine B. Heard, George A. Gregory, Oral ketamine preanesthetic medication in children. Anesthesiology. ,vol. 76, pp. 28- 33 ,(1992) , 10.1097/00000542-199201000-00004
Lawrence H. Feld, Jean B. Negus, Paul F. White, Oral Midazolam Preanesthetic Medication in Pediatric Outpatients Anesthesiology. ,vol. 73, pp. 831- 834 ,(1990) , 10.1097/00000542-199011000-00006
L SAARNIVAARA, L LINDGREN, U.-M. KLEMOLA, COMPARISON OF CHLORAL HYDRATE AND MIDAZOLAM BY MOUTH AS PREMEDICANTS IN CHILDREN UNDERGOING OTOLARYNGOLOGICAL SURGERY BJA: British Journal of Anaesthesia. ,vol. 61, pp. 390- 396 ,(1988) , 10.1093/BJA/61.4.390
Robert T. Blouin, Harry A. Seifert, H. Daniel Babenco, Pattilyn F. Conard, Jeffrey B. Gross, Propofol depresses the hypoxic ventilatory response during conscious sedation and isohypercapnia. Anesthesiology. ,vol. 79, pp. 1177- 1182 ,(1993) , 10.1097/00000542-199312000-00007
S. J. Parnis, J. A. Foate, J. H. van der Walt, T. Short, C. E. Crowe, Oral midazolam is an effective premedication for children having day-stay anaesthesia. Anaesthesia and Intensive Care. ,vol. 20, pp. 9- 14 ,(1992) , 10.1177/0310057X9202000102
K. G. Stewart, S. J. Rowbottom, A. W. Aitken, S. Rajendram, D. A. Sudhaman, Oral ketamine premedication for paediatric cardiac surgery--a comparison with intramuscular morphine (both after oral trimeprazine). Anaesthesia and Intensive Care. ,vol. 18, pp. 11- 14 ,(1990) , 10.1177/0310057X9001800103