Metabolite profiling in identifying metabolic biomarkers in older people with late-onset type 2 diabetes mellitus
作者： Zhi Yang Tam , Sean Pin Ng , Ling Qiao Tan , Chih-Hsien Lin , Dietrich Rothenbacher
DOI: 10.1038/S41598-017-01735-Y
关键词:
摘要: Regulation of blood glucose requires precise coordination between different endocrine systems and multiple organs. Type 2 diabetes mellitus (T2D) arises from a dysregulated response to elevated levels in the circulation. Globally, prevalence T2D has increased dramatically all age groups. older adults is associated with higher mortality reduced functional status, leading rate institutionalization. Despite potential healthcare challenges presence elderly, pathogenesis phenotype late-onset not well studied. Here we applied untargeted metabolite profiling urine samples people without using ultra-performance liquid-chromatography mass-spectrometry (UPLC-MS) identify urinary biomarkers for elderly. Statistical modeling measurements thorough validation structural assignment liquid chromatography tandem (LC-MS/MS) have led identification T2D. Lower phenylalanine, acetylhistidine, cyclic adenosine monophosphate (cAMP) were found subjects validated commercial standards. Elevated 5′-methylthioadenosine (MTA), which previously only been implicated animal model diabetes, was
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