Protein kinase Dyrk1 activates cAMP response element-binding protein during neuronal differentiation in hippocampal progenitor cells.
作者： Eun Jin Yang , Young Soo Ahn , Kwang Chul Chung
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摘要: Dyrk is a dual specific protein kinase thought to be involved in normal embryo neurogenesis and brain development. Defects/imperfections this have been suggested play an important role the mental retardation of patients with Down's syndrome. The transcriptional factor cAMP response element-binding (CREB) has implicated formation many types synaptic plasticity, such as learning memory. In present study we show that Dyrk1 activity markedly induced during differentiation immortalized hippocampal progenitor (H19-7) cells. addition neurogenic factor, basic fibroblast growth H19-7 cells results increased binding active CREB. addition, directly phosphorylates CREB, leading stimulation subsequent CRE-mediated gene transcription neuronal Blockade activation significantly inhibits neurite outgrowth well CREB phosphorylation by factor. These findings suggest central nervous system
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