Combined organ and hematopoietic cells for transplantation tolerance of HLA mismatched grafts

摘要: Methods and compositions are provided for combined transplantation of a solid organ hematopoietic cells to an HLA mismatched recipient, where tolerance the graft is established through development persistent mixed chimerism. An individual with chimerism, usually period at least six months, able withdraw from use immunosuppressive drugs after time sufficient establish tolerance.