[7-OR]: L-Citrulline administration increases the arginine/ADMA ratio, decreases blood pressure and improves vascular function in obese pregnant women

摘要: Objectives Maternal obesity significantly increases the risk of preeclampsia, but mechanism(s) underlying this relationship are unknown. Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor nitric oxide synthase and independent factor cardiovascular disease. ADMA elevated in preeclampsia. Oral citrulline readily metabolized to arginine, arginine/ADMA ratio associated with improved vascular function. The objective randomized double blind placebo controlled trial was investigate effect administration on function healthy obese pregnant women. Methods 24 women were enrolled at 16 weeks gestation 3 g L -citrulline/day for 3 weeks or placebo. ADMA, SDMA, blood pressure, uterine artery resistive pulsatility indices (RI & PI), brachial flow-mediated dilation (FMD) measured baseline (enrollment) after enrollment. Results arginine/ADMA, RI PI, FMD not different between groups Citrulline increased compared treated (308.1 ± 166.7 vs. 163.0 ± 41.3, p  = 0.03) PI (1.03 ± 0.05 1.20 ± 0.07, following treatment. Blood pressure remained lower 35 weeks pre-delivery among citrulline. 6–12 months post-partum. Conclusions Supplementation during pregnancy maternal women, persistently pressure. supplementation mid-pregnancy may reduce adverse effects adaptation by increasing bioavailability. Disclosures R. Powers: None. T.L. Weissgerber: S. McGonigal: A. Myerski: M. Gallaher: P.D. Speer: J.M. Roberts: Jeyabalan: C.A. Hubel: