Insulin down-regulates TRAIL expression in vascular smooth muscle cells both in vivo and in vitro.
作者： Federica Corallini , Claudio Celeghini , Clara Rizzardi , Assunta Pandolfi , Sara Di Silvestre
DOI: 10.1002/JCP.21006
关键词:
摘要: To dissect the effect of hyperinsulinemia versus hyperglycemia on TNF-related apoptosis inducing ligand (TRAIL) expression in macrovascular district, we measured TRAIL mRNA and protein four groups animals: streptozotocin (SZT)-induced diabetic rats, vehicle-treated control animals, rats treated with insulin non-diabetic insulin. While aortas did not show significant differences respect to both vivo for 16 days showed a decrease either rats. Moreover, vitro treatment rat human vascular smooth muscle cells (VSMC) induced down-regulation protein. addition recombinant VSMC promoted dose-dependent release bioactive nitric oxide (NO), this was significantly counteracted by pre-exposure These findings suggest that might act as an endogenous regulator tone chronic elevation contribute abnormalities characterizing type-2 diabetes mellitus down-regulating activity.
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Bernadette R. Gochuico, Jie Zhang, Bei Yang Ma, Ann Marshak-Rothstein, Alan Fine, TRAIL expression in vascular smooth muscle. American Journal of Physiology-lung Cellular and Molecular Physiology. ,vol. 278, ,(2000) , 10.1152/AJPLUNG.2000.278.5.L1045
G ZAULI, P SECCHIERO, The role of the TRAIL/TRAIL receptors system in hematopoiesis and endothelial cell biology. Cytokine & Growth Factor Reviews. ,vol. 17, pp. 245- 257 ,(2006) , 10.1016/J.CYTOGFR.2006.04.002
Heeje Kim, Katharine A. Whartenby, Robert W. Georgantas, John Wingard, Curt I. Civin, Human CD34+ hematopoietic stem/progenitor cells express high levels of FLIP and are resistant to Fas-mediated apoptosis. Stem Cells. ,vol. 20, pp. 174- 182 ,(2002) , 10.1634/STEMCELLS.20-2-174
Michael I. Oliverio, Thomas M. Coffman, Angiotensin-II-receptors: new targets for antihypertensive therapy. Clinical Cardiology. ,vol. 20, pp. 3- 6 ,(1997) , 10.1002/CLC.4960200103
Timothy A. McCaffrey, Chenzhong Fu, Baoheng Du, Sukru Eksinar, K. Craig Kent, Harry Bush, Karl Kreiger, Todd Rosengart, Myron I. Cybulsky, Eric S. Silverman, Tucker Collins, High-level expression of Egr-1 and Egr-1-inducible genes in mouse and human atherosclerosis. Journal of Clinical Investigation. ,vol. 105, pp. 653- 662 ,(2000) , 10.1172/JCI8592
Mingui Fu, Xiaojun Zhu, Jifeng Zhang, Jian Liang, Yiming Lin, Luning Zhao, Markus U Ehrengruber, Yuqing E Chen, None, Egr-1 target genes in human endothelial cells identified by microarray analysis. Gene. ,vol. 315, pp. 33- 41 ,(2003) , 10.1016/S0378-1119(03)00730-3
Ciro Indolfi, Daniele Torella, Luigi Cavuto, Alberto M. Davalli, Carmela Coppola, Giovanni Esposito, Mariolina V. Carriero, Antonio Rapacciuolo, Emilio Di Lorenzo, Eugenio Stabile, Cinzia Perrino, Alaide Chieffo, Francesco Pardo, Massimo Chiariello, Effects of balloon injury on neointimal hyperplasia in streptozotocin-induced diabetes and in hyperinsulinemic nondiabetic pancreatic islet-transplanted rats. Circulation. ,vol. 103, pp. 2980- 2986 ,(2001) , 10.1161/01.CIR.103.24.2980
P. Secchiero, C. Zerbinati, E. Rimondi, F. Corallini, D. Milani, V. Grill, G. Forti, S. Capitani, G. Zauli, TRAIL promotes the survival, migration and proliferation of vascular smooth muscle cells Cellular and Molecular Life Sciences. ,vol. 61, pp. 1965- 1974 ,(2004) , 10.1007/S00018-004-4197-6
Paola Secchiero, Arianna Gonelli, Claudio Celeghini, Prisco Mirandola, Lia Guidotti, Giuseppe Visani, Silvano Capitani, Giorgio Zauli, Activation of the nitric oxide synthase pathway represents a key component of tumor necrosis factor-related apoptosis-inducing ligand-mediated cytotoxicity on hematologic malignancies Blood. ,vol. 98, pp. 2220- 2228 ,(2001) , 10.1182/BLOOD.V98.7.2220
Assunta Pandolfi, Alfredo Grilli, Carlo Cilli, Antonia Patruno, Andrea Giaccari, Sara Di Silvestre, Maria Anna De Lutiis, Giuliana Pellegrini, Fabio Capani, Agostino Consoli, Mario Felaco, Phenotype modulation in cultures of vascular smooth muscle cells from diabetic rats: association with increased nitric oxide synthase expression and superoxide anion generation. Journal of Cellular Physiology. ,vol. 196, pp. 378- 385 ,(2003) , 10.1002/JCP.10325