Spectral analysis of heart rate variability following human heart transplantation: evidence for functional reinnervation

摘要: To determine the status of innervation in long-term human donor allografts, power spectrum heart rate variability was analysed 9 post-transplant patients and 7 healthy control subjects. The mean follow-up 17.8 months (range: 2-37 months). Continuous ECG signals were recorded throughout a 15-min rest period. An R-R interval tachogram generated an autoregressive model using linear predictive coding, applied to data. In 8 transplant frequency oscillations irregular, broad based widely dispersed from 0 1 Hz. patterns resembled white noise consistent with dissociation allograft recipient's central nervous system. contrast, one patient displayed indistinguishable that This pattern contained two distinct spectral bands; corresponding patient's respiratory at 0.2 Hz low Mayer wave 0.1 Atropine abolished (vagal) peak. Except for this time (33 compared group 17.6 months), there no clinical characteristics which distinguished others. While remaining allografts significantly higher than controls (95.3 vs 64.5 bt/min; P less 0.001) standard deviation narrower (0.7 4.86; 0.01). variance normal fourfold greater SD other patients.(ABSTRACT TRUNCATED AT 250 WORDS)