Photosensitizing effects of hypericin on head neck squamous cell carcinoma in vitro
作者： Wiebke Laffers , Ann-Christin Busse , Jens Mahrt , Phuc Nguyen , Andreas O. H. Gerstner
DOI: 10.1007/S00405-014-2984-8
关键词:
摘要: Clinical outcome of patients suffering from head neck squamous cell carcinomas is still poor due to recurrent disease and surgical limitations. There a demand for multimodality approaches new therapeutic options. Hypericin promising phototoxic drug which was investigated its effects on carcinoma cells in vitro. FaDu incubated with or without hypericin were illuminated (450-700 nm, 50,000 lx) different time periods. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide- terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling assay used score metabolic apoptotic activity. Even after the shortest illumination showed massive reduction metabolism excessive apoptosis. This present even lowest concentration. Cells not affected. These photosensitizing could be suitable clinical application lead development an intraoperative photodynamic therapy carcinomas.
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de Witte P, Ursaciuc C, Hãlãlãu F, Coman G, Merlevede W, Waelkens E, Alecu M, Photodynamic treatment of basal cell carcinoma and squamous cell carcinoma with hypericin. Anticancer Research. ,vol. 18, pp. 4651- 4654 ,(1998)
Basic principles and applications Springer-Verlag. ,(1984) , 10.1007/978-3-642-82215-5
Marcos Tatagiba, Florian Roser, Klaus Dietz, Michael Weller, Rainer Ritz, Martin Müller, Selim Kuci, Hypericin: a promising fluorescence marker for differentiating between glioblastoma and neurons in vitro. International Journal of Oncology. ,vol. 27, pp. 1543- 1549 ,(2005) , 10.3892/IJO.27.6.1543
Hans Brockmann, Mohammed Nagib Haschad, Karl Maier, Fritz Pohl, Über das Hypericin, den photodynamisch wirksamen Farbstoff aus Hypericum perforatum Naturwissenschaften. ,vol. 27, pp. 550- 550 ,(1939) , 10.1007/BF01495453
Patrizia Agostinis, Zerihun Assefa, Annelies Vantieghem, Jackie R Vandenheede, Wilfried Merlevede, Peter De Witte, Apoptotic and anti-apoptotic signaling pathways induced by photodynamic therapy with hypericin Advances in Enzyme Regulation. ,vol. 40, pp. 157- 182 ,(2000) , 10.1016/S0065-2571(99)00021-7
Waseem Jerjes, Tahwinder Upile, Aviva Petrie, Andrew Riskalla, Zaid Hamdoon, Michael Vourvachis, Kostas Karavidas, Amrita Jay, Ann Sandison, Gareth J Thomas, Nicholas Kalavrezos, Colin Hopper, Clinicopathological parameters, recurrence, locoregional and distant metastasis in 115 T1-T2 oral squamous cell carcinoma patients Head & Neck Oncology. ,vol. 2, pp. 9- 9 ,(2010) , 10.1186/1758-3284-2-9
Anastasia Karioti, Anna Rita Bilia, Hypericins as potential leads for new therapeutics. International Journal of Molecular Sciences. ,vol. 11, pp. 562- 594 ,(2010) , 10.3390/IJMS11020562
Theodossis A. Theodossiou, John S. Hothersall, Peter A. De Witte, Alexandros Pantos, Patrizia Agostinis, The Multifaceted Photocytotoxic Profile of Hypericin Molecular Pharmaceutics. ,vol. 6, pp. 1775- 1789 ,(2009) , 10.1021/MP900166Q
Guido Seitz, Steven Warmann, Sorin Armeanu, Heike Heitmann, Peter Ruck, Robert Hoffman, Jörg Fuchs, Johannes Wessels, In vitro photodynamic therapy of childhood rhabdomyosarcoma. International Journal of Oncology. ,vol. 30, pp. 615- 620 ,(2007) , 10.3892/IJO.30.3.615
R. Ritz, R. Daniels, S. Noell, G.C. Feigl, V. Schmidt, A. Bornemann, K. Ramina, D. Mayer, K. Dietz, W.S.L. Strauss, M. Tatagiba, Hypericin for visualization of high grade gliomas: first clinical experience. Ejso. ,vol. 38, pp. 352- 360 ,(2012) , 10.1016/J.EJSO.2011.12.021