Synthesis of 3H-imidazo[4,5-b] pyridine with evaluation of their anticancer and antimicrobial activity
作者： Rohini Narayan Shelke , Dattatraya Navnath Pansare , Chandrakant Dhondiram Pawar , Arun Khandu Deshmukh , Rajendra Pandu Pawar
DOI: 10.5155/EURJCHEM.8.1.25-32.1522
关键词:
摘要: Microwave assisted and conventional synthetic methods of new 6-bromo-2-(substituted)-3 H -imidazo[4,5-b]pyridine its derivatives are described, which were obtained in reduced reaction times, higher yields, cleaner reactions than previously described methods. All the synthesized compounds characterized, screened for their anticancer antimicrobial activity. Among 3b 3k shows prominent antibacterial activity compound 3f both antifungal Compounds 3h 3j against breast cancer cell lines, MCF-7 BT-474. These results suggest that imidazo[4,5-b]pyridine moiety may serve as a promising template synthesis agents further study is required evaluation mechanism action.
eurjchem.com
sci-hub.st 参考文章(43)
Michael J. Rybak, Ronda L. Akins, Emergence of methicillin-resistant Staphylococcus aureus with intermediate glycopeptide resistance: clinical significance and treatment options. Drugs. ,vol. 61, pp. 1- 7 ,(2001) , 10.2165/00003495-200161010-00001
H. Hänel, W. Raether, A more sophisticated method of determining the fungicidal effect of water-insoluble preparations with a cell harvester, using miconazole as an example. Mycoses. ,vol. 31, pp. 148- 154 ,(2009) , 10.1111/J.1439-0507.1988.TB03718.X
KC Nicolaou, R Scarpelli, B Bollbuck, B Werschkun, MMA Pereira, M Wartmann, K-H Altmann, D Zaharevitz, R Gussio, P Giannakakou, Chemical synthesis and biological properties of pyridine epothilones Chemistry & Biology. ,vol. 7, pp. 593- 599 ,(2000) , 10.1016/S1074-5521(00)00006-5
Rajender S. Varma, Solvent-free organic syntheses. using supported reagents and microwave irradiation Green Chemistry. ,vol. 1, pp. 43- 55 ,(1999) , 10.1039/A808223E
Bakr F. Abdel-Wahab, Ghada E.A. Awad, Farid A. Badria, Synthesis, antimicrobial, antioxidant, anti-hemolytic and cytotoxic evaluation of new imidazole-based heterocycles. European Journal of Medicinal Chemistry. ,vol. 46, pp. 1505- 1511 ,(2011) , 10.1016/J.EJMECH.2011.01.062
Dattatraya N. Pansare, Nayeem A. Mulla, Chandrakant D. Pawar, Vikas R. Shende, Devanand B. Shinde, One pot three components microwave assisted and conventional synthesis of new 3-(4-chloro-2-hydroxyphenyl)-2-(substituted) thiazolidin-4-one as antimicrobial agents Bioorganic & Medicinal Chemistry Letters. ,vol. 24, pp. 3569- 3573 ,(2014) , 10.1016/J.BMCL.2014.05.051
Harshad G. Kathrotiya, Nilav A. Patel, Ranjan G. Patel, Manish P. Patel, An efficient synthesis of 3′-quinolinyl substituted imidazole-5-one derivatives catalyzed by zeolite and their antimicrobial activity Chinese Chemical Letters. ,vol. 23, pp. 273- 276 ,(2012) , 10.1016/J.CCLET.2011.11.022
Zahed Karimi-Jaberi, Mohammad Barekat, One-pot synthesis of tri- and tetra-substituted imidazoles using sodium dihydrogen phosphate under solvent-free conditions Chinese Chemical Letters. ,vol. 21, pp. 1183- 1186 ,(2010) , 10.1016/J.CCLET.2010.06.012
Mary Mader, Alfonso de Dios, Chuan Shih, Rosanne Bonjouklian, Tiechao Li, Wesley White, Beatriz López de Uralde, Concepción Sánchez-Martinez, Miriam del Prado, Carlos Jaramillo, Eugenio de Diego, Luisa M. Martín Cabrejas, Carmen Dominguez, Carlos Montero, Timothy Shepherd, Robert Dally, John E. Toth, Arindam Chatterjee, Sehila Pleite, Jaime Blanco-Urgoiti, Leticia Perez, Mario Barberis, María José Lorite, Enrique Jambrina, C. Richard Nevill, Paul A. Lee, Richard C. Schultz, Jeffrey A. Wolos, Li C. Li, Robert M. Campbell, Bryan D. Anderson, Imidazolyl benzimidazoles and imidazo[4,5- b ]pyridines as potent p38α MAP kinase inhibitors with excellent in vivo antiinflammatory properties Bioorganic & Medicinal Chemistry Letters. ,vol. 18, pp. 179- 183 ,(2008) , 10.1016/J.BMCL.2007.10.106
Ji-Feng Liu, Mira Kaselj, Yuko Isome, Ping Ye, Katie Sargent, Kevin Sprague, Djamel Cherrak, Christopher J. Wilson, Ying Si, Daniel Yohannes, Shi-Chung Ng, Design and synthesis of a quinazolinone natural product-templated library with cytotoxic activity. ACS Combinatorial Science. ,vol. 8, pp. 7- 10 ,(2006) , 10.1021/CC050108G