Rest-activity rhythm profiles associated with manic-hypomanic and depressive symptoms

摘要: Abstract Rest-activity rhythm (RAR) disturbances are associated with mood disorders. But there remains a need to identify the particular RAR profiles psychiatric symptom dimensions. Establishing such would support development of tools that track 24-h sleep-wake phenotypes signaling clinical heterogeneity. We used data-driven clustering in 145 adults aged 36–82 years (mean = 60, standard deviation = 9). Then we evaluated dimensions (including positive and negative affect, depressive, manic-hypomanic, panic-agoraphobic, substance use symptoms) these empirically-derived profiles. Clustering identified three sub-groups characterized, on average, by: (1) earlier more robust RARs (“earlier/robust,” n = 55, 38%); (2) later irregular (“later/irregular,” n = 31, 21%); (3) narrower active period (“later/narrower,” n = 59, 41%). Compared “earlier/robust” group: “later/irregular” group had higher levels lifetime manic-hypomanic symptoms (β (standard error) = 0.80 (0.22) standardized units, p = 0.0004) depression error) = 0.73 (0.21) p = 0.0009); “later/narrower” error) = 0.48 (0.18) p = 0.0076). These associations persisted after adjustments for sleep continuity duration, suggesting distinct behavioral correlates Longitudinal studies needed confirm whether characteristics contribute risk manic and/or depressive episodes, they reflect consequences disturbance (e.g., quality life or disability). Opportunities monitor intervene objectively-assessed could facilitate better mental health related outcomes.