Abstract PR1: Oncogenic ETS over-expression mimics RAS/MAPK signaling in prostate cells

摘要: Abstract The aberrant expression of an oncogenic ETS transcription factor is implicated in the progression majority prostate cancers. cancer chromosomal rearrangements that drive over-expression are associated with one four genes, ERG, ETV1, ETV4 and ETV5. It not clear how these genes differ from numerous other expressed normal prostate. We report proteins, but factors, enhance cell migration. Genome-wide binding analysis matched this specific biological function to occupancy a unique set genomic sites highlighted by presence AP-1 sequences. ETS/AP-1 sequences prototypical RAS-responsive elements, proteins activated RAS/MAPK transcriptional program absence MAPK activation. Thus, overexpression can replace pathway activation cells. description regulated, RAS-responsive, gene provides resource for understanding role factors both cancers either or RAS mutations. This abstract also presented as Poster B26. Citation Format: Peter C. Hollenhorst, Mary W. Ferris, Megan A. Hull, Heejoon Chae, Sun Kim, Barbara J. Graves. Oncogenic mimics signaling cells [abstract]. In: Proceedings AACR Special Conference on Advances Prostate Cancer Research; 2012 Feb 6-9; Orlando, FL. Philadelphia (PA): AACR; Res 2012;72(4 Suppl):Abstract nr PR1.