N-Terminal Pro-B-Type Natriuretic Peptide and Mortality in Renal Transplant Recipients Versus the General Population

摘要: Background. Mortality rates are higher in renal transplant recipients (RTR) than the general population (GP). It is unknown what risk factors account for this difference. Methods. We prospectively followed a cohort of 606 RTR 3026 person-years, during which 95 died. A GP 3234 subjects was 24,940 130 Results. All investigated factors, except ethnicity, body mass index, and total cholesterol, differed significantly between cohorts, with an adverse profile RTR. The age-adjusted gender-adjusted hazard ratio mortality 6.2 (95% confidence interval [Cl] 4.6-8.3) compared GP, reduced to 2.4 Cl 1.6-3.6), 4.3 3.0-6.1), 5.0 3.5-7.3) after additional adjustment differences N-terminal pro-B-type natriuretic peptide (NT-proBNP), creatinine clearance, need antihypertensive medication, respectively (all P Conclusions. Elevated NT-proBNP, low medication stronger GP. increased seen may well be related cardiac failure rather "accelerated atherosclerosis."