Zur Konfiguration der Jaborosalactone, ein neuer Abbauweg für Withanolide
作者： Rudolf Tschesche , Klaus Annen , Peter Welzel
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摘要: Die 14α.17αH.20S-Konfiguration der Jaborosalactone wurde durch Verknupfung von Jaborosalacton D (4a) mit bekannten Steroiden bewiesen. Es ein neuer Withanolid-Abbau entwickelt, dessen entscheidende Schritte die Reduktion 6 zu 7, Hydrogenolyse 9 und Atheroffnung bei 15 sind. On the Configuration of Jaborosalactones, a New Degradation Scheme for Withanolides The 14α.17αH.20S-configuration in Jaborosalactones was demonstrated by degradation to known steroids. A new scheme used, crucial steps which were hydrogenation give hydrogenolysis 9, and ether cleavage 15.
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