L-Leucinthiol — A potent inhibitor of leucine aminopeptidase
作者： William W.-C. Chan
DOI: 10.1016/0006-291X(83)90414-X
关键词:
摘要: L-leucinthiol (2-amino-4-methyl-1-pentanethiol) was designed as an inhibitor of leucine aminopeptidase by analogy with sulfhydryl inhibitors other zinc-containing peptidases. It synthesized from L-leucinol and shown to be a potent competitive the microsomal porcine kidney (Ki = 2.2 X 10(-8) M). The results suggest that mechanism may similar metalloproteases.
elsevier.com
sci-hub.se 参考文章(18)
W W Chan, P Dennis, W Demmer, K Brand, Inhibition of leucine aminopeptidase by amino acid hydroxamates. Journal of Biological Chemistry. ,vol. 257, pp. 7955- 7957 ,(1982) , 10.1016/S0021-9258(18)34279-0
Alan L. Maycock, Donna M. DeSousa, Linda G. Payne, Jan ten Broeke, Mu Tsu Wu, Arthur A. Patchett, Inhibition of thermolysin by N-carboxymethyl dipeptides. Biochemical and Biophysical Research Communications. ,vol. 102, pp. 963- 969 ,(1981) , 10.1016/0006-291X(81)91632-6
Norikazu Nishino, James C. Powers, Peptide hydroxamic acids as inhibitors of thermolysin. Biochemistry. ,vol. 17, pp. 2846- 2850 ,(1978) , 10.1021/BI00607A023
Richard E. Galardy, Voula Kontoyiannidou-Ostrem, Zbigniew P. Kortylewicz, Inhibition of angiotensin converting enzyme by phosphonic amides and phosphonic acids. Biochemistry. ,vol. 22, pp. 1990- 1995 ,(1983) , 10.1021/BI00277A039
HAMAO UMEZAWA, TAKAAKI AOYAGI, HIROYUKI SUDA, MASA HAMADA, TOMIO TAKEUCHI, BESTATIN, AN INHIBITOR OF AMINOPEPTIDASE B, PRODUCED BY ACTINOMYCETES The Journal of Antibiotics. ,vol. 29, pp. 97- 99 ,(1976) , 10.7164/ANTIBIOTICS.29.97
Lars Andersson, Timothy C. Isley, Richard Wolfenden, alpha-aminoaldehydes: transition state analogue inhibitors of leucine aminopeptidase. Biochemistry. ,vol. 21, pp. 4177- 4180 ,(1982) , 10.1021/BI00260A040
Larry D. Byers, Richard Wolfenden, Binding of the by-product analog benzylsuccinic acid by carboxypeptidase A Biochemistry. ,vol. 12, pp. 2070- 2078 ,(1973) , 10.1021/BI00735A008
P.L. Birch, H.A. El-Obeid, M. Akhtar, The preparation of chloromethylketone analogues of amino acids: Inhibition of leucine aminopeptidase Archives of Biochemistry and Biophysics. ,vol. 148, pp. 447- 451 ,(1972) , 10.1016/0003-9861(72)90163-4
Miguel A. Ondetti, Michael E. Condon, Joyce Reid, Emily F. Sabo, Hong S. Cheung, David W. Cushman, Design of potent and specific inhibitors of carboxypeptidases A and B. Biochemistry. ,vol. 18, pp. 1427- 1430 ,(1979) , 10.1021/BI00575A006
M-A. Coletti-Previero, A.Crastes de Paulet, H. Mattras, A. Previero, Amino acid hydroxamates as inhibitors of the human enkephalin-degrading aminopeptidase. Biochemical and Biophysical Research Communications. ,vol. 107, pp. 465- 469 ,(1982) , 10.1016/0006-291X(82)91514-5