Accumulation of p16CDKN2A in Response to Ultraviolet Irradiation Correlates with a Late S-G2-Phase Cell Cycle Delay

摘要: p16 is the product of CDKN2A locus, which mutated or deleted in many human tumors. In response to nonlethal UVC irradiation, HeLa cells accumulate elevated levels p16. The accumulation delayed 8–12 h following irradiation and correlates with S-phase G2 delays, decreasing as recover recommence normal cell growth. maximum correlated delay. UVC-induced cycle delay was absent lines derived from that did not express a melanoma line for