Plasma cell labeling index and β2-microglobulin predict survival independent of thymidine kinase and C-reactive protein in multiple myeloma

摘要: The plasma cell labeling index (PCLI) and serum beta 2-microglobulin (beta 2M) are independent prognostic factors in multiple myeloma (MM). Recently, levels of thymidine kinase (TK) C-reactive protein (CRP) have been shown to value. We studied 107 patients with newly diagnosed determine whether TK CRP values added information not already available using the PCLI 2M. Univariate survival analysis showed significance for PCLI, TK, 2M, age, albumin, CRP. Multivariate that only 2M significance. curves were better separated than other combinations variables. Among nine under age 65 low eight alive almost 6 years after starting chemotherapy. These good-risk could be identified by standard clinical features. Although creatinine calcium normal, features such as bone lesions, osteoporosis, fracture, anemia present stage distribution was similar study. In conclusion, measured at diagnosis factors. They must considered when interpreting results trials should helpful counseling designing new trials. When known, do add useful additional information.