Concurrent Use of Behavioral/Functional Testing in Existing Reproductive and Developmental Toxicity Screens: Practical Considerations

摘要: Behavioral/functional testing is a required segment of reproductive/developmental toxicity safety evaluations pharmaceuticals to be marketed in the United Kingdom and Japan. Should current momentum for mandating behavioral teratology continue, these may become components submitted regulatory agencies States. The selection appropriate tests practical application existing present an array problems. Although there vast number different types tests, specific methodologies many are incompatible with standard endpoints protocols. There multiple inherent methodological problems associated incorporation into currently designed review. These include relative ...