High frequency of thyroid abnormalities in polycystic ovary syndrome

摘要: The prevalence of thyroid abnormalities (TA) has not been sufficiently assessed in polycystic ovary syndrome (PCOS). Our aim was to evaluate this relationship. In prospective study 194 women were included. PCOS group consisted 142 patients (diagnosed by Rotterdam 2003 criteria) and the control included 52 age-matched healthy women. Fasting blood samples drawn for free T4, thyrotropin, thyroperoxidase antibodies (TPOAb), fasting insulin, glucose HOMA-IR calculated. A total had either autoimmune thyroiditis (AIT+) and/or subclinical hypothyroidism (HSC) (36.6%) (thyroid abnormalities:TA+) compared with 7 (13.5%), accounting more than a five fold higher TA patients, controls (adjusted odds ratio: 5.6; CI 95%: 2.1 -14.9; p<0.001). TA+ significantly FI values without (p<0.05). These results demonstrate high rate young women, associated levels HOMA-IR. As PCOS, autoimmunity may have profound impact on reproductive health, our data indicate that should be screened TA.