Control of T reg and T H 17 cell differentiation by the aryl hydrocarbon receptor

摘要: Regulatory T cells (Treg) expressing the transcription factor Foxp3 control autoreactive components of immune system. The development Treg is reciprocally related to that pro-inflammatory producing interleukin-17 (TH17). Although cell dysfunction and/or TH17 dysregulation are thought contribute autoimmune disorders, little known about physiological pathways generation these lineages. Here we report identification ligand-activated aryl hydrocarbon receptor (AHR) as a regulator and differentiation in mice. AHR activation by its ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin induced functional suppressed experimental encephalomyelitis. On other hand, 6-formylindolo[3,2-b]carbazole interfered with development, boosted increased severity encephalomyelitis Thus, regulates both ligand-specific fashion, constituting unique target for therapeutic immunomodulation. best mediating toxicity aromatic hydrocarbons such dioxin: leads production detoxification enzymes. has been intensely studied relation toxicology cancer research, but no mechanistic connection system was known. Now two groups role maintaining balance between T-lymphocyte populations — part regulation dealing tolerance self-antigens pathogen clearance. Both also show affects encephalitis, mouse model multiple sclerosis. This work raises possibility stimulation environmental factors could be involved disease, point possible drug cellular number environment contaminants. It shown here induce regulatory when bound TCCD promote FICZ.