Chromosomes and causation of human cancer and leukemia.XXII. Karyotypic changes in malignant melanoma
作者： Surabhi Kakati , S. Y. Song , Avery A. Sandberg
DOI: 10.1002/1097-0142(197709)40:3<1173::AID-CNCR2820400328>3.0.CO;2-T
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摘要: Detailed karyotypic analysis with G- and C-banding has been performed on cells of four malignant melanomas. The modal number in two cases was the hypodiploid range, chromosome numbers varying from 39 to 43. These tumors had 5 13 marker chromosomes. other were polyploid 63 157 a minimum 11 maximum 40 Chromosome no. 1 more frequently involved aberrations than any chromosome. most common breakpoints this 1q21, 1q25 1q32. Frequent also noticed centromeric region various In 1, however, area does not seem be involved. chromosomes 1q25, 1q32, 5p13, 9q13, 11q23, 12q13. No markers among these melanoma, but are unrelated tumors.
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