Dissecting impulsivity and its relationships to drug addictions

摘要: Addictions are often characterized as forms of impulsive behavior. That said, it is noted that impulsivity a multidimensional construct, spanning several psychological domains. This review describes the relationship between varieties and addiction-related behaviors, nature causal two, underlying neurobiological mechanisms promote behaviors. We conclude available data strongly support notion both risk factor for, consequence of, drug alcohol consumption. While evidence indicating subtypes behavior uniquely informative--either biologically or with respect to their relationships addictions--is convincing, multiple lines study link distinct low dopamine D2 receptor function perturbed serotonergic transmission, revealing shared subtypes. Therefore, common biological framework involving monoaminergic transmitters in key frontostriatal circuits may self-administration Further dissection these needed before next phase genetic genomic discovery will be able reveal sources vulnerability for addiction indexed by impulsivity.