Aceturato de diminazeno e dipropionato de imidocarb no controle de infecção por Trypanosoma evansi em Rattus norvegicus infectados experimentalmente
作者： Aleksandro Schafer da Silva , Camila Tochetto , Régis Adriel Zanette , Felipe Pierezan , Daniel Ricardo Rissi
DOI: 10.1590/S0103-84782008000500025
关键词:
摘要: The aim of this study was to evaluate the efficacy diminazene aceturate and imidocarb dipropionate in control Trypanosoma evansi infection rats (Rattus norvegicus) experimentally infected. Fifty-four male were inoculated through intraperitoneal route with 104 T. trypomastigotes. evaluated daily by periferic blood smears examination treated when eight flagellated parasites observed 1000x microscopic field. Two therapeutics protocols used. first one included Groups A, B, C, D which submitted a single dose testing drugs administered intramuscular at day 0 again smears. second protocol (Groups E, F, G, H) same treatment five consecutive days. Four (Group I) used as not any treatment. Tested did show curative effect protocol, since parasitaemia evident few days after use resulted elimination trypomastigotes from circulation. In case euthanized 90. recurred 30 administration dipropionate. Histologically, no lesions found liver or kidney. Diminazene is effective treating trypanosomosis consecutively.
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