Observations on 6-mercaptopurine activity in Saccharomyces cerevisiae
作者： Alison Puttick , Malcolm Phillips , Norman K. Todd
DOI: 10.1111/J.1574-6968.1985.TB01636.X
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摘要: Yeast strains carrying the allele su-pur are sensitive to a number of purine analogues including 6-mercaptopurine (6MP), whereas su-pur+-carrying insensitive [1]. Experimentation into 6MP insensitivity revealed that agent was being utilized as nutrient source both by su-pur+ strain, and cells with an adenine requirement. As reportedly excrete hypoxanthine [1] it is suggested biochemistry differs in yeast man, degradation via sulfinic acid may occur.
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sci-hub.se 参考文章(14)
W.G. Sorenson, J.P. Simpson, Tong-Man Ong, Comparison of mutagenic and recombinogenic effects of some adenine analogues in Saccharomyces cerevisiae D7. Mutation Research. ,vol. 82, pp. 95- 100 ,(1981) , 10.1016/0027-5107(81)90141-X
W PICKERING, R WOODS, The uptake and incorporation of purines by wild-type Saccharomyces cerevisiae and a mutant resistant to 4-aminopyrazolo (3, 4-d) pyrimidine Biochimica et Biophysica Acta. ,vol. 264, pp. 45- 58 ,(1972) , 10.1016/0304-4165(72)90115-8
Allan H. Roush, Lillian M. Questiaux, A. J. Domnas, The active transport and metabolism of purines in the yeast, candida utilis Journal of Cellular and Comparative Physiology. ,vol. 54, pp. 275- 286 ,(1959) , 10.1002/JCP.1030540310
J. Frank Henderson, Inhibition of microbial growth by naturally-occuring purine bases and ribonucleosides Pharmacology & Therapeutics. ,vol. 8, pp. 605- 627 ,(1980) , 10.1016/0163-7258(80)90078-9
S. Sora, L. Panzeri, G.E. Magni, Molecular specificity of 2-aminopurine in Saccharomyces cerevisiae. Mutation Research. ,vol. 20, pp. 207- 213 ,(1973) , 10.1016/0027-5107(73)90190-5
Cheryl Wallis, David Wilkie, Mitochondrial activity of 2,6-diaminopurine in Saccharomyces cerevisiae. Molecular Genetics and Genomics. ,vol. 173, pp. 307- 313 ,(1979) , 10.1007/BF00268641
Susan Armitt, Robin A. Woods, Purine-excreting mutants of Saccharomyces cerevisiae. I. Isolation and genetic analysis. Genetics Research. ,vol. 15, pp. 7- 17 ,(1970) , 10.1017/S0016672300001324
J W Carpenter, L M Rose, D J Adamson, J A Nelson, Mechanisms of action of 6-thioguanine, 6-mercaptopurine, and 8-azaguanine Cancer Research. ,vol. 35, pp. 2872- 2878 ,(1975)
Christopher A. Lomax, Trevor S. Gross, Robin A. Woods, New Mutant Types at the ade3 Locus of Saccharomyces cerevisiae Journal of Bacteriology. ,vol. 107, pp. 1- 7 ,(1971) , 10.1128/JB.107.1.1-7.1971
Tomihiko Higuchi, Haruto Uchino, Toru Nakamura, Effects of phenobarbital and endotoxin on the lethality and metabolism of 6-mercaptopurine in male BALB/c mice. Cancer Research. ,vol. 37, pp. 3668- 3671 ,(1977)