Self-assembly of Pt(II) based nanoscalar ionic hexagons and their anticancer potencies
作者： Santosh Kumar , Khushwant Singh , Pankaj Garg , Neeladri Das , Achintya Jana
DOI: 10.1016/J.ICA.2018.09.009
关键词:
摘要: Abstract Two nanoscalar and supramolecular metallacycles were self-assembled by employing a predesigned pyrazine based molecular “acceptor” clip with two different ditopic pyridyl “donor” tectons. The platina macrocycles characterized multinuclear NMR spectroscopy, mass spectrometry (ESI-MS), elemental analyses. Molecular modelling using PM6 semiempirical orbital method suggested these having dimensions hexagonal cavities. Additionally, interactions of studied three carcinoma cell lines. Results suggest that anticancer properties higher than their organometallic precursor. capable efficiently reducing proliferation cancer lines (A549, HepG2, HeLa). activity the larger was even at lower concentrations IC50 values are comparable cisplatin. TUNEL assay induces apoptotic death. These results could find potential biomedical applications as therapeutic agents.
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