Multiobjective optimization of SMB and varicol process for chiral separation

摘要: The multiobjective optimization of continuous countercurrent chromatography separation units, such as simulated moving bed (SMB) and Varicol, is considered. Varicol system based on a nonsynchronous shift the inlet outlet ports instead synchronous one used in SMB technology. problem complicated by relative large number decision variables, including flow rates lengths, well discontinuous ones, column configuration. It also important to reformulate multiobjective, since factors affecting cost given process are multiple often conflict with each other. A typical example simultaneous maximization productivity purity corresponding products. new procedure genetic algorithm allows handling these complex problems. An existing literature chiral model was illustrate potential this procedure. This work offered unique opportunity compare optimal performance achievable technologies.