Cerebrospinal fluid markers for prediction of Alzheimer's disease
作者： Henrik Zetterberg , Lars-Olof Wahlund , Kaj Blennow
DOI: 10.1016/J.NEULET.2003.08.011
关键词:
摘要: Abstract A major diagnostic challenge when people seek advice for cognitive dysfunction is to differentiate between mild impairment (MCI) and incipient Alzheimer's disease (AD). We show that a combination of three cerebrospinal fluid biochemical markers, total-tau, phospho-tau β-amyloid(1-42), can detect AD among patients fulfilling the criteria MCI with sensitivity 68% (95% CI 45–86%) specificity 97% 83–100%). The usefulness these markers further emphasized by finding positive predictive value 94% negative 81%.
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