Effects of Histamine on Lymphocytes

摘要: Histamine originally identified in 1900s is an important mediator of allergic disease, asthma and inflammation. has modulatory effects on different subpopulations lymphoid cells. The pharmacologic histamine are mediated through four types membrane receptors, H1R, H2R, H3R H4R, which all heptahelical G-protein-coupled receptors. receptors possess structural features including seven putative transmembrane domain, amino terminal glycosylation sites, phosphorylation sites for protein kinase A C. Stimulation H1R H2R activates Gq Gs respectively, whereas both H4R coupled to Gi/o. affects a number immune processes regulation T cells, antibody isotopes, antigen presenting cells peripheral cell tolerance. conventional wisdom regarding the Th1/Th2 subsets that it shifts responses from Th1 Th2 resulting asthmatic disease. While expression H2 been well characterized; there not consensus function H1 It suggested may show dominant increased H2R. cytokine release by have established. suppresses cytokines stimulates secretion via recently discovered H4 drawn considerable interest pertaining their response receptor dendritic regulates chemotaxis migration mast eosinophils, modulates also cytokine-dependent signal transduction pathways JAK-STAT pathway. This chapter provides overview recent developments understanding role its regulating effector involved disease asthma.