[Safety and efficacy of L-carnitine and tadalafil for late-onset hypogonadism with ED: a randomized controlled multicenter clinical trial].

摘要: Objective: To evaluate the safety and effect of L-carnitine combined with tadalafil in treatment late-onset hypogonadism( LOH) erectile dysfunction( ED).Methods: We randomly divided 140 cases LOH ED aged 40- 70 years into a control group to receive + testosterone undecanoate tadalafil,respectively.After 8 weeks treatment,we obtained scores on IIEF-5 Aging Male Symptoms( AMS),observed changes levels sex hormones,analyzed results routine blood test PSA level,and evaluated medication.Results: Finally,110 were included,60 50 control.After medication,the AMS significantly improved as compared baseline both group( 17.7 ± 3.5 vs 10.2 2.7 36.2 6.5 48.8 ±5.8) 16.7 2.6 9.3 2.4 35.8 6.6 50.7 5.0)( P 0.05),with no significant differences between two groups( 0.05).As for medication,there groups before after treatment( 0.05).Two patients showed level 4 μg / L,which was confirmed be caused by prostatitis during follow-up.Conclusion: is safe effective ED.