Pendrin localizes to the adrenal medulla where it modulates catecholamine release (701.1)

摘要: Pendrin is an aldosterone-sensitive, Na+-independent Cl-/HCO3- exchanger expressed in intercalated cells within the renal cortex where it modulates blood pressure. Since pendrin gene ablation stimulates release of renin, but not aldosterone, we hypothesized that adrenal gland and function. Thus, examined rat mouse mRNA protein abundance by PCR, immunoblot immunohistochemistry responses wild type null mice. was detected lysates from type, In both mice rats, observed medulla cortex. produces catecholamines, further experiments plasma epinephrine to 5 20 min immobilization stress Basal concentration similar Immobilization ...