Nitric oxide synthase inhibitor suppresses the ototoxic side effect of cisplatin in guinea pigs.
作者： Ken-ichi Watanabe , Alexander Hess , Wilhelm Bloch , Olaf Michel
DOI: 10.1097/00001813-200006000-00011
关键词:
摘要: Cisplatin is known to cause inner ear damage (ototoxicity). The role of inducible nitric oxide synthase (iNOS) in the cochlea guinea pigs after injections cisplatin or a combination and NOS inhibitor (NG-nitro-L-arginine methyl ester, L-NAME) i.p. was examined electro-and immunohistochemically. auditory brain stem responses (ABR) were measured prior injection 3 days injection. Three injection, cochleas immunohistochemically for iNOS. We found that iNOS expressed cisplatin- L-NAME/ cisplatin-treated cochlea. threshold shift ABR significant group, whereas it decreased L-NAME/cisplatin group. catalyzed high NO levels lead dysfunction. Our results indicate mediates ototoxicity cisplatin.
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