The immune complex pathogenesis of glomerulonephritis and pulmonary vasculitis in Behçet's disease

摘要: A kidney and lung biopsy were performed on a patient with active Behcet's disease renal pulmonary involvement. Histologic, immunohistochemical electron microscopic studies of the specimen revealed focal segmental necrotizing glomerulonephritis characterized by presence numerous subendothelial occasional intramembranous deposits containing immunoglobulin G (IgG), third component complement (C3), fourth (C4) fibrin(ogen). Histologic showed an acute venulitis septal capillaritis associated identical within walls affected vessels. Circulating immune complexes detected in patient's serum Raji cell assay. The findings indicate that vasculitis occasionally occurring are due to deposition circulating antigen-antibody complexes. In addition, they strongly suggest majority major minor manifestations disease, such as uveitis, cutaneous vasculitis, synovitis meningoencephalitis, result vascular complex deposition.