Stable growth transformation of human T lymphocytes by herpesvirus saimiri.

摘要: Abstract Herpesvirus saimiri induces T-cell lymphomas in various species of New World monkeys and rabbits, it is able to immortalize monkey T lymphocytes vitro. Sequences responsible for these effects have been localized a region the genome that varies significantly among virus subgroups A, B, C. We now report infection human blood thymocytes with strains subgroup C, contrast viruses other subgroups, yields continuously proliferating lines phenotype mature CD4- or CD8-positive cells. Infection Herpes-virus C can thus be used generate variety immunological developmental studies.