A prospective trial of inhaled nitric oxide in clinical lung transplantation.
作者： Abbas Ardehali , Hillel Laks , Michael Levine , Robert Shpiner , David Ross
DOI: 10.1097/00007890-200107150-00022
关键词:
摘要: Background. Reperfusion injury (RI) is a major cause of mortality and morbidity among lung transplant recipients. We sought to determine if prophylactic administration inhaled nitric oxide (NO) recipients at reperfusion would prevent RI. also hypothesized that NO proves ineffective in preventing RI then it may improve pulmonary hemodynamics gas exchange the subset patients who develop Methods. After informed consent, 28 consecutive, adult received 20 ppm reperfusion. was withdrawn for 15 min 6 12 hr after reperfusion, were measured. Results. Five (18%) developed Withdrawal this resulted significant rise mean artery pressure reduction oxygenation index. All five with kept on until full functional recovery allograft weaned from mechanical ventilation. None required extracorporeal membrane support; early group 20% (1/5). The remaining 23 without had uneventful postoperative course ventilation within 36 transplantation. Conclusions. Prophylactic-inhaled does not human However, NO, started improves reduces those
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sci-hub.se 参考文章(20)
J A Abate, W L Henry, J E Albina, Nitric oxide production is required for murine resident peritoneal macrophages to suppress mitogen-stimulated T cell proliferation. Role of IFN-gamma in the induction of the nitric oxide-synthesizing pathway. Journal of Immunology. ,vol. 147, pp. 144- 148 ,(1991)
N Hogg, V M Darley-Usmar, M T Wilson, S Moncada, Production of hydroxyl radicals from the simultaneous generation of superoxide and nitric oxide. Biochemical Journal. ,vol. 281, pp. 419- 424 ,(1992) , 10.1042/BJ2810419
X L Ma, A S Weyrich, D J Lefer, A M Lefer, Diminished basal nitric oxide release after myocardial ischemia and reperfusion promotes neutrophil adherence to coronary endothelium. Circulation Research. ,vol. 72, pp. 403- 412 ,(1993) , 10.1161/01.RES.72.2.403
G. Della Rocca, C. Coccia, F. Pugliese, M. Antonini, L. Pompei, F. Ruberto, F. Venuta, C. Ricci, A. Gasparetto, Intraoperative inhaled nitric oxide during anesthesia for lung transplant International Society for Organ Sharing Congress. ,vol. 29, pp. 3362- 3366 ,(1997) , 10.1016/S0041-1345(97)00944-5
Neil K. Worrall, Carlos H. Boasquevisque, Mitchell D. Botney, Thomas P. Misko, Patrick M. Sullivan, Jon H. Ritter, T. Bruce Ferguson, G. Alexander Patterson, Inhibition of inducible nitric oxide synthase ameliorates functional and histological changes of acute lung allograft rejection Transplantation. ,vol. 63, pp. 1095- 1101 ,(1997) , 10.1097/00007890-199704270-00008
Alan J.B. Kirk, Ian W. Colquhoun, John H. Dark, Lung Preservation: A Review of Current Practice and Future Directions The Annals of Thoracic Surgery. ,vol. 56, pp. 990- 1000 ,(1993) , 10.1016/0003-4975(93)90378-U
Michael K. Pasque, Joel D. Cooper, Larry R. Kaiser, David A. Haydock, Anastasios Triantafillou, Elbert P. Trulock, Improved technique for bilateral lung transplantation: Rationale and initial clinical experience The Annals of Thoracic Surgery. ,vol. 49, pp. 785- 791 ,(1990) , 10.1016/0003-4975(90)90023-Y
Sudhir Sundaresan, Gregory D. Trachiotis, Motoi Aoe, G.Alexander Patterson, Joel D. Cooper, Donor lung procurement: Assessment and operative technique The Annals of Thoracic Surgery. ,vol. 56, pp. 1409- 1413 ,(1993) , 10.1016/0003-4975(93)90699-I
N K Worrall, W D Lazenby, T P Misko, T S Lin, C P Rodi, P T Manning, R G Tilton, J R Williamson, T B Ferguson, Modulation of in vivo alloreactivity by inhibition of inducible nitric oxide synthase. Journal of Experimental Medicine. ,vol. 181, pp. 63- 70 ,(1995) , 10.1084/JEM.181.1.63
Ian Adatia, Craig Lillehei, John H. Arnold, John E. Thompson, Regina Palazzo, James C. Fackler, David L. Wessel, Inhaled nitric oxide in the treatment of postoperative graft dysfunction after lung transplantation The Annals of Thoracic Surgery. ,vol. 57, pp. 1311- 1318 ,(1994) , 10.1016/0003-4975(94)91382-X