K-tuple frequency analysis: from intron/exon discrimination to T-cell epitope mapping.

摘要: Publisher Summary This chapter presents methods that take advantage of the frequencies occurrence all subsequences length k (k-tuples) as computed from sequence interest, ranging introdexon discrimination to T-cell epitope mapping. A set FORTRAN 77 programs has been designed perform tasks involved in general methodology described here. includes computation k-tuple frequency catalogs data bank subsets or private collections, software tools for consultation, editing, and manipulation these well coded sequences, interactive display profiles. At very first level, reference catalog can be constituted test itself. The method then provides clear graphical information about repeated versus unique regions molecule. profiles any type always used a tool represent large sequences (several kilobases) way allowing one pick up at glance some characteristic features.