Hydrogen peroxide protects yeast cells from inactivation by ionizing radiation: a radiobiological paradox.
作者： M. SARAN K. WINKLER and B. FELLERHOFF
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摘要: Purpose : To elucidate mechanisms of the interaction hydrogen peroxide with chloride-derived cytotoxins under steady-state irradiation conditions and to determine effects on cell viability. Materials Methods Yeast cells were suspended in phosphatebuffered saline exposed 60Co gamma -irradiation different conditions. The colony-forming ability was determined. Results Irradiation PBS produces H2 O2 HOCl simultaneously. Under slightly acidic low oxygen tension yield exceeds that while at physiological pH normoxic HOCl. Both substances react each other rapidly a pH-dependent way, even during an lasts several seconds. As is about 1000-fold more toxic than strain Saccharomyces cerevisiae used these experiments, it evident radiation-induced damage will be large. If, contrast, are irradiated...
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