On the role of GABA as an inhibitory neurotransmitter in inferior colliculus neurons: iontophoretic studies

摘要: Significant neurochemical, immunocytochemical, and ligand binding studies support a role for GABA as an inhibitory neurotransmitter in the inferior colliculus (IC). The present study attempted to satisfy some of remaining criteria establishing transmitter identity by utilizing iontophoretic application onto IC neurons agents affecting action gamma-aminobutyric acid (GABA). examined include GABA, GABAB agonist (baclofen), GABAA antagonist (bicuculline), uptake inhibitor (nipecotic acid), benzodiazepine (flurazepam), thought exert its actions on receptor complex. Application results inhibition spontaneous firing acoustically evoked responses neurons. effect is enhanced simultaneous nipecotic or flurazepam. These well baclofen produce reductions when applied alone higher doses. can be blocked bicuculline, (binaural) also selectively low doses this antagonist. data along with previous different techniques fulfill many establishment important colliculus.